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Article
Blood lead level among school children in an industrial city of Nepal
Gautam K , Pradhan S , Thuppil V , Pyakurel D, Shrestha A
Journal of Pathology of Nepal
DOI: 10.3126/jpn.v7i1.16943

Lead is a heavy metal ubiquitous in our environment which has no physiological role in biological systems. It s rather a cumulative toxicant that affects multiple body systems and is particularly harmful to young children. Its widespread use has resulted in extensive human exposure and significant public health problems in many parts of the world.
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Article
"Detection of Hemoglobinopathies by HPLC in a Referral Clinical Laboratory in Nepal "
Abha Shrestha, Vivek Pant, Keyoor Gautam, Devish Pyakurel, Santosh Pradhan
Nepalese Medical Journal
DOI: DOI 10.3126/nmj.v3i1.29477

Hemoglobin fraction analysis by ion-exchange in HPLC has the advantage of quantifying HbF and
HbA2 along with hemoglobin variant screening in a single reproducible system making it an excellent tool to screen for hemoglobin variants and hemoglobinopathy.
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Article
"Screening for blood lead level in reproductive age group individuals in Kathmandu"
"Vivek Pant, Keyoor Gautam, Devish Pyakurel, Vijay Sharma, Nutan Sharma, Santosh Pradhan, Abha Shrestha"
Journal of Pathology of Nepal
DOI: DOI : 10.3126/jpn.v11i2.38102

It is justifiable to screen for blood-lead levels in the reproductive age group individual in Nepal. Policymakers
are encouraged to review recommendations of other organizations, including national scientific publications
regarding lead and its health hazard.
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Article
"Blood glucose concentration compared in EDTA/F plasma and serum in a referral clinical laboratory in Nepal"
Vivek Pant, Keyoor Gautam, Santosh Pradhan, Devish Pyakurel, Abha Shrestha
Journal of Pathology of Nepal
DOI: DOI : 10.3126/jpn.v10i2.32351

Blood glucose measurement in serum can be accepted if the serum separation via centrifugation is achieved within 30 minutes. The avoidance of an extra amount of blood draw in a separate NaF tube and better turn-around-time are advantages of using serum tubes. It should be mandatory to have a centrifuge at all collection centers to achieve blood separation within a reasonable time.
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Article
"Comparison of calculated LDL-cholesterol using the Friedewald formula and de Cordova formula with a directly measured LDL-cholesterol in Nepalese population"
Santosh Pradhan , Keyoor Gautam, Devish Pyakurel
Practical Laboratory Medicine
DOI: https://doi.org/10.1016/j.plabm.2020.e00165

In a Nepalese population, there is better agreement of the Friedewald formula with a directly measured LDL-C compared to the de
Cordova formula. However, this has to be verified in a larger population, including different conditions in which the Friedewald formula
was found to be inaccurate.
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Article
Variation in Laboratory Reports: Causes other than Laboratory Error
Santosh Pradhan, Keyoor Gautam, Vivek Pant
Journal of Nepal Medical Association
DOI: https://doi.org/10.31729/jnma.6022

It is rare to get the same results when a sample of the individual is measured at different times, even if the state of health in the individual has not been changed. If such difference in test results from repeated testing is observed, physicians and health care professionals should also be aware of possible factors other than laboratory error.
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Article
"Postprandial Blood Glucose can be less than Fasting Blood Glucose and this is not a Laboratory Error"
Vivek Pant, Keyoor Gautam,Santosh Pradhan
Journal of Nepal Medical Association
DOI: doi:10.31729/jnma.3985

The aim of the present article is to aware healthcare providers about the factors that can cause FBG level higher than PPBG.
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Article
Miscarriage and Anti-TPO antibodies
Santosh Pradhan, Keyoor Gautam
Journal of Pathology of Nepal
DOI: DOI: 10.3126/jpn.v%vi%i.20895

An association between the risk of a miscarriage and anti TPO antibodies has been largely confirmed in several population studies even in absence of overt thyroid dysfunction.
 
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Article
Isolated Increase in Serum Aspartate Aminotransferase in an Asymptomatic Young Nepalese Female
Vivek Pant, Santosh Pradhan, Keyoor Gautam, Devish Pyakurel
The Journal of Applied Laboratory Medicine
DOI: https://doi.org/10.1093/jalm/jfz004

Patients having persistently raised AST level without other abnormal liver indices should be tested for macroAST. Early diagnosis of macroAST avoids unnecessary investigations or invasive procedures and decreases patient anxiety.
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