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Adults.
INCREASE IN: Infections, multiple myeloma, autoimmunity diseases such as lupus or collagen diseases, chronic inflammatory diseases such as syphilis, waldenstrom's macroglobulinemia, liver disease, Rheumatoid arthritis, ulcerative colitis, carcinoid syndrome, kidney disease.
DECREASE IN: Renal disease, hepatic dysfunction, celiac disease, inflammatory bowel disease (IBD), acute hemolytic anemia, agammaglobulinemia and hypogammaglobulinemia.