An association between the risk of a miscarriage and anti TPO antibodies has been largely confirmed in several population studies even in absence of overt thyroid dysfunction.
Autoimmune thyroid disorders are common in women of reproductive age. Anti-TPO antibody and
thyroglobulin antibody are frequently found to be associated. Anti-TPO antibodies are responsible for
the activation of complement and are thought to be significantly involved in thyroid dysfunction. In early
pregnancy women with anti TPO antibodies are prone to develop subclinical or overt hypothyroidism
leading to adverse obstetric and fetal outcomes. An association between the risk of a miscarriage and anti
TPO antibodies has also been reported even in absence of overt thyroid dysfunction. However, screening
for these antibodies and Levothyroxin supplement in anti TPO antibodies -positive euthyroid pregnant
women has not been established yet.